Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.559


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_882147200.351.9e-01Click!
LOC729991-MEF2Bchr19_-_19163916-0.302.6e-01Click!
MEF2Achr15_+_97923737-0.224.1e-01Click!
MEF2Bchr19_-_191420900.214.4e-01Click!
MEF2Dchr1_-_1547371890.194.8e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_69539255 1.958 NM_032578
MYPN
myopalladin
chr3_-_39209075 1.855 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr6_-_123999640 1.744 NM_006073
TRDN
triadin
chr5_+_155686333 1.633 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr2_+_88148413 1.551 NM_198274
SMYD1
SET and MYND domain containing 1
chr8_+_40130143 1.450 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_-_190635566 1.324 NM_005259
MSTN
myostatin
chr3_+_42702014 1.095 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr18_-_3209986 1.086 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr6_+_27885692 1.063 NM_003536
HIST1H3H
histone cluster 1, H3h
chr2_+_204279442 1.060 NM_006139
CD28
CD28 molecule
chr7_-_113346284 1.049 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr5_-_83052606 1.021 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr4_-_23500706 0.990 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_-_139654807 0.975 NM_153235
TXLNB
taxilin beta
chr6_+_26266311 0.964 NM_021063
NM_138720
HIST1H2BD

histone cluster 1, H2bd

chr22_+_24468168 0.951 MYO18B
myosin XVIIIB
chr2_-_69033515 0.940 NM_182536
GKN2
gastrokine 2
chr10_-_62373828 0.931 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr12_-_55931172 0.911 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr17_+_7125702 0.901 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr17_+_35075124 0.895 NM_003673
TCAP
titin-cap (telethonin)
chr22_+_24468110 0.886 NM_032608
MYO18B
myosin XVIIIB
chr1_+_92405196 0.871 NM_015237
KIAA1107
KIAA1107
chr2_+_233099113 0.865 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr14_+_38805622 0.844 CTAGE5
CTAGE family, member 5
chr3_+_8750485 0.827 NM_033337
NM_001234
CAV3

caveolin 3

chr1_-_199657468 0.824 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr10_-_75085754 0.796 NM_001114133
SYNPO2L
synaptopodin 2-like
chr3_+_139550134 0.792 NM_001085049
MRAS
muscle RAS oncogene homolog
chr10_+_50177192 0.773 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr6_-_26232109 0.770 NM_003526
HIST1H2BG
HIST1H2BC
histone cluster 1, H2bg
histone cluster 1, H2bc
chr1_-_16217025 0.749 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr4_-_186934059 0.735 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr6_-_33268177 0.731 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr6_+_132000134 0.725 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr17_-_61655915 0.722 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr10_-_81698840 0.692 NM_003019
SFTPD
surfactant protein D
chr2_-_236837726 0.683 NM_212556
ASB18
ankyrin repeat and SOCS box containing 18
chr1_-_199613427 0.681 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr9_-_103185621 0.678 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr17_-_10313600 0.675 NM_017533
MYH4
myosin, heavy chain 4, skeletal muscle
chr16_+_31132842 0.668 NM_001008274
TRIM72
tripartite motif containing 72
chr5_+_53787187 0.657 NM_006308
HSPB3
heat shock 27kDa protein 3
chr6_+_131508153 0.654 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr13_-_35327798 0.650 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr17_-_10265991 0.640 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr7_-_96471544 0.638 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_53991672 0.632 NM_138569
C6orf142
chromosome 6 open reading frame 142
chr2_+_204279624 0.629 CD28
CD28 molecule
chr2_+_170074457 0.618 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr5_+_121493113 0.603 NM_207317
ZNF474
zinc finger protein 474
chr8_+_55691179 0.601 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr1_+_556968 0.595


chr4_-_110942783 0.595 NM_000204
CFI
complement factor I
chr14_-_103058568 0.590 CKB
creatine kinase, brain
chr8_+_67201684 0.584 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr12_+_118100977 0.580 NM_014365
HSPB8
heat shock 22kDa protein 8
chr8_-_27171814 0.580 NM_030795
STMN4
stathmin-like 4
chr1_-_26266571 0.575 NM_032588
TRIM63
tripartite motif containing 63
chr6_+_131613196 0.574 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr18_-_3209846 0.571 MYOM1
myomesin 1, 185kDa
chr4_+_120029426 0.565 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr7_+_63892198 0.544 NM_001160183
NM_006524
ZNF138

zinc finger protein 138

chr1_+_557269 0.544


chr5_-_95774444 0.541 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr7_-_91632525 0.540 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr19_+_12064077 0.536 ZNF788
zinc finger family member 788
chr8_-_72431274 0.535 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr4_-_177427252 0.532 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr11_-_123695302 0.532 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_+_204509698 0.531 NM_012092
ICOS
inducible T-cell co-stimulator
chr10_+_88418147 0.525 NM_001171610
LDB3
LIM domain binding 3
chr2_+_149603226 0.516 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr5_-_36187710 0.503 NM_001007527
LMBRD2
LMBR1 domain containing 2
chr14_-_20563698 0.497 NDRG2
NDRG family member 2
chr14_-_20563722 0.496 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr14_-_103058865 0.495 NM_001823
CKB
creatine kinase, brain
chr1_+_158352143 0.492 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_27113018 0.492 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_150328153 0.491 NM_001008536
TCHHL1
trichohyalin-like 1
chr9_-_99740243 0.483 NM_197978
HEMGN
hemogen
chr12_+_100394787 0.483 NM_152323
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr2_-_199922047 0.482 SATB2
SATB homeobox 2
chr4_+_41057322 0.481 LIMCH1
LIM and calponin homology domains 1
chr7_+_154943466 0.481 NM_001427
EN2
engrailed homeobox 2
chr2_+_238712101 0.481 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr4_+_88748704 0.480 NM_014208
DSPP
dentin sialophosphoprotein
chr9_-_205892 0.478 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr9_-_14858974 0.477 FREM1
FRAS1 related extracellular matrix 1
chr1_+_65503011 0.476 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_-_10500189 0.475 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr11_+_1897374 0.474 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr9_+_134884627 0.473 EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr21_+_14510336 0.471 NM_144770
RBM11
RNA binding motif protein 11
chr4_-_110942576 0.466 CFI
complement factor I
chr3_+_139550368 0.464 MRAS
muscle RAS oncogene homolog
chr4_+_120276386 0.460 NM_016599
MYOZ2
myozenin 2
chr10_-_75080784 0.459 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_+_144124547 0.459 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_-_181540631 0.454 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr7_-_150847698 0.450 RHEB
Ras homolog enriched in brain
chr18_+_18969724 0.448 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr21_-_18697829 0.447 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr12_-_47679459 0.445 DDN
dendrin
chr11_-_101292462 0.444 NM_178127
ANGPTL5
angiopoietin-like 5
chr2_+_168383427 0.444 NM_020981
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr10_-_52315436 0.443 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_150422474 0.439 NM_000096
CP
ceruloplasmin (ferroxidase)
chr10_+_88418243 0.439 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr12_+_50731457 0.435 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr17_+_29606408 0.434 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr6_-_27914095 0.430 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr1_+_201729893 0.430 NM_014359
OPTC
opticin
chr3_+_185300660 0.429 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr1_+_62835759 0.429 NM_014495
ANGPTL3
angiopoietin-like 3
chr7_-_150847624 0.428 RHEB
Ras homolog enriched in brain
chr14_+_99309688 0.428 EML1
echinoderm microtubule associated protein like 1
chr19_+_3884100 0.417 NM_170678
ITGB1BP3
integrin beta 1 binding protein 3
chr15_+_76171981 0.417 NM_001101404
SH2D7
SH2 domain containing 7
chr1_-_202595666 0.417 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr21_-_33107813 0.415 NM_001162495
NM_001162496
NM_019596
C21orf62


chromosome 21 open reading frame 62


chr1_-_23623713 0.414 NM_003196
TCEA3
transcription elongation factor A (SII), 3
chr4_-_64957595 0.413 NM_001010874
TECRL
trans-2,3-enoyl-CoA reductase-like
chr7_-_135263737 0.411 MTPN
LUZP6
myotrophin
leucine zipper protein 6
chr17_-_31441390 0.411 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr16_-_70591377 0.411 NM_181536
PKD1L3
polycystic kidney disease 1-like 3
chr2_-_148495642 0.408 NM_181742
ORC4
origin recognition complex, subunit 4
chr7_+_129693938 0.407 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr8_-_124818754 0.404 NM_001003954
NM_004306
ANXA13

annexin A13

chr13_-_50315832 0.404 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr14_-_69616616 0.403 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr4_+_74566325 0.403 NM_001133
AFM
afamin
chr9_-_96395828 0.402 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr11_+_48466844 0.400 NM_001005512
OR4A47
olfactory receptor, family 4, subfamily A, member 47
chr6_-_128281434 0.398 NM_001164687
THEMIS
thymocyte selection associated
chr14_+_31868229 0.397 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_42773146 0.396 NM_001080850
CCDC30
coiled-coil domain containing 30
chr10_-_92671005 0.396 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_117554999 0.393 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr18_+_20294590 0.392 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr10_-_52315390 0.392 A1CF
APOBEC1 complementation factor
chr2_-_228206045 0.389 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr7_-_150847529 0.388 RHEB
Ras homolog enriched in brain
chr1_-_116184846 0.385 NM_001111061
NHLH2
nescient helix loop helix 2
chr19_+_57540493 0.384 NM_173530
ZNF610
zinc finger protein 610
chr1_-_157014048 0.383 NM_001005278
OR6N2
olfactory receptor, family 6, subfamily N, member 2
chr10_-_69267774 0.382 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr7_+_75769927 0.382 HSPB1
heat shock 27kDa protein 1
chr17_-_44400952 0.382 NM_004123
GIP
gastric inhibitory polypeptide
chr11_+_18390421 0.381 NM_002301
NM_017448
LDHC

lactate dehydrogenase C

chr1_-_56817717 0.380 PPAP2B
phosphatidic acid phosphatase type 2B
chr14_+_57964148 0.378


chr10_-_14919973 0.378 NM_001029954
CDNF
cerebral dopamine neurotrophic factor
chr6_+_27914301 0.378 NM_003520
HIST1H2BN
histone cluster 1, H2bn
chr5_+_137447479 0.375 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr10_+_96688399 0.375 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr7_+_93862137 0.372 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr8_-_122722674 0.371 NM_005328
HAS2
hyaluronan synthase 2
chr19_-_20540380 0.370 NM_001159293
ZNF737
zinc finger protein 737
chr12_+_15590552 0.370 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_25629968 0.369 NM_018202
TMEM57
transmembrane protein 57
chr5_-_42847716 0.368 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_116112684 0.364 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_+_102744921 0.363 NM_144632
TMEM182
transmembrane protein 182
chr4_-_56153135 0.361 NM_152401
PDCL2
phosducin-like 2
chr17_-_59437782 0.359 NM_000873
ICAM2
intercellular adhesion molecule 2
chr3_+_190147633 0.358 TPRG1
tumor protein p63 regulated 1
chrX_+_131179886 0.358


chr6_+_12825818 0.358 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr5_-_58688428 0.358 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_10362583 0.356 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr2_-_197383120 0.354 NM_213608
C2orf66
chromosome 2 open reading frame 66
chr2_+_38746555 0.354 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr6_-_48186868 0.352 C6orf138
chromosome 6 open reading frame 138
chr1_+_239882202 0.352 NM_144625
WDR64
WD repeat domain 64
chr14_+_23670514 0.349 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr2_-_148494732 0.347 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr1_-_116112853 0.346 CASQ2
calsequestrin 2 (cardiac muscle)
chr4_-_95482994 0.344 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr8_+_76614757 0.344 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_-_147665783 0.344 HIST2H2BF
histone cluster 2, H2bf
chr3_+_120982020 0.343 NM_003889
NM_033013
NR1I2

nuclear receptor subfamily 1, group I, member 2

chr4_+_86918870 0.342 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr1_-_148959945 0.341 NM_032132
HORMAD1
HORMA domain containing 1
chr4_+_146820805 0.341 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr3_+_35658852 0.339 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_-_186970366 0.338 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr3_-_150533948 0.337 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_+_12724406 0.336 NM_017682
BEST2
bestrophin 2
chr6_-_27548438 0.335 NM_007149
ZNF184
zinc finger protein 184
chrX_+_70438352 0.335 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr1_-_156923111 0.333 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr17_+_5913149 0.333 WSCD1
WSC domain containing 1
chr12_-_120591938 0.329 NM_173855
MORN3
MORN repeat containing 3
chr4_-_187114407 0.328 SORBS2
sorbin and SH3 domain containing 2
chr5_+_34875025 0.327 NM_144725
TTC23L
tetratricopeptide repeat domain 23-like
chr10_+_80569464 0.326 ZMIZ1
zinc finger, MIZ-type containing 1
chr1_+_154605626 0.325 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr7_+_94953148 0.325 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.66 3.67e-03 GO:0030049 muscle filament sliding
4.66 3.67e-03 GO:0033275 actin-myosin filament sliding
2.47 3.73e-03 GO:0003012 muscle system process
4.53 5.19e-03 GO:0070252 actin-mediated cell contraction
2.05 2.56e-02 GO:0061061 muscle structure development
3.64 3.89e-02 GO:0030048 actin filament-based movement

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.88 8.84e-10 GO:0030016 myofibril
4.06 5.08e-09 GO:0030017 sarcomere
3.66 5.43e-09 GO:0043292 contractile fiber
3.75 1.07e-08 GO:0044449 contractile fiber part
1.34 2.64e-03 GO:0005576 extracellular region
3.87 2.76e-03 GO:0031674 I band
3.42 3.59e-03 GO:0000786 nucleosome
1.49 3.86e-03 GO:0044421 extracellular region part
9.46 1.66e-02 GO:0005577 fibrinogen complex
3.84 2.84e-02 GO:0030018 Z disc
1.50 3.78e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.97 2.03e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor